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From: WordNet (r) 2.0

 tranquillise
      v 1: make calm or still; "quiet the dragons of worry and fear"
           [syn: calm, calm down, quiet, tranquilize, tranquillize,
            quieten, lull, still] [ant: agitate]
      2: cause to be calm or quiet as by administering a sedative to;
         "The patient must be sedated before the operation" [syn: sedate,
          calm, tranquilize, tranquillize] [ant: stimulate]