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From: MDBG CC-CEDICT Chinese-English Dictionary 漢英字典

 命途坎坷 [ㄇㄧㄥˋ ㄊㄨˊ ㄎㄢˇ ㄎㄜˇ; ming4 tu2 kan3 ke3]
 to have a tough life
 to meet much adversity in one's life