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From: MDBG CC-CEDICT Chinese-English Dictionary 漢英字典

 疑難雜症 [ㄧˊ ㄋㄢˊ ㄗㄚˊ ㄓㄥˋ; yi2 nan2 za2 zheng4]
 dubious or hard-to-treat cases (medicine)
 hard cases