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From: MDBG CC-CEDICT Chinese-English Dictionary 漢英字典

 苦心孤詣 [ㄎㄨˇ ㄒㄧㄣ ㄍㄨ ㄧˋ; ku3 xin1 gu1 yi4]
 to make painstaking efforts (idiom); after much trouble
 to work hard at sth