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2 definitions found

From: Webster's Revised Unabridged Dictionary (1913)

 Loco disease. Veter. A chronic nervous affection of cattle, horses, and sheep, caused by eating the loco weed and characterized by a slow, measured gait, high step, glassy eyes with defective vision, delirium, and gradual emaciation.
 

From: WordNet (r) 2.0

 loco disease
      n : a disease of livestock caused by locoweed poisoning;
          characterized by weakness and lack of coordination and
          trembling and partial paralysis [syn: locoism]