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From: Webster's Revised Unabridged Dictionary (1913)

 Op·tic·al·ly, adv.
 1. By optics or sight.
 2. With reference to optics.
 Optically active, Optically inactive Chem. Physics, terms used of certain isomeric substances which, while identical with each other in other respects, differ in this, viz., that they do or do not produce right-handed or left-handed circular polarization of light.  See optical activity.
 Optically positive, Optically negative. See under Refraction.