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From: Webster's Revised Unabridged Dictionary (1913)

 Tire, v. t. To exhaust the strength of, as by toil or labor; to exhaust the patience of; to wear out (one's interest, attention, or the like); to weary; to fatigue; to jade.
    Tired with toil, all hopes of safety past.   --Dryden.
 To tire out, to weary or fatigue to exhaustion; to harass.
 Syn: -- To jade; weary; exhaust; harass. See Jade.