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From: MDBG CC-CEDICT Chinese-English Dictionary 漢英字典

 毫無效果 [ㄏㄠˊ ㄨˊ ㄒㄧㄠˋ ㄍㄨㄛˇ; hao2 wu2 xiao4 guo3]
 to no avail
 achieving nothing
 totally ineffective
 to have no effect
 to fall flat (esp. of joke or speech that is completely ignored)