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From: Webster's Revised Unabridged Dictionary (1913)

 Sys·tem·ic a.
 1. Of or relating to a system; common to a system; as, the systemic circulation of the blood.
 2. Anat. & Physiol. Of or pertaining to the general system, or the body as a whole; as, systemic death, in distinction from local death; systemic circulation, in distinction from pulmonic circulation; systemic diseases.
 Systemic death. See the Note under Death, n., 1.