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From: Webster's Revised Unabridged Dictionary (1913)

 Ail v. t. [imp. & p. p. Ailed p. pr. & vb. n. Ailing.]  To affect with pain or uneasiness, either physical or mental; to trouble; to be the matter with; -- used to express some uneasiness or affection, whose cause is unknown; as, what ails the man? I know not what ails him.
    What aileth thee, Hagar?   --Gen. xxi. 17.
 Note: ☞ It is never used to express a specific disease. We do not say, a fever ails him; but, something ails him.