De·spite n.
1. Malice; malignity; spite; malicious anger; contemptuous hate.
With all thy despite against the land of Israel. --Ezek. xxv. 6.
2. An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
A despite done against the Most High. --Milton.
In despite, in defiance of another's power or inclination.
In despite of, in defiance of; in spite of. See under Spite. “Seized my hand in despite of my efforts to the contrary.” --W. Irving.
In your despite, in defiance or contempt of you; in spite of you. [Obs.]