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From: Webster's Revised Unabridged Dictionary (1913)

 De·spite n.
 1. Malice; malignity; spite; malicious anger; contemptuous hate.
    With all thy despite against the land of Israel.   --Ezek. xxv. 6.
 2. An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
    A despite done against the Most High.   --Milton.
 In despite, in defiance of another's power or inclination.
 In despite of, in defiance of; in spite of. See under Spite. “Seized my hand in despite of my efforts to the contrary.” --W. Irving.
 In your despite, in defiance or contempt of you; in spite of you. [Obs.]