De·spite n.
  1. Malice; malignity; spite; malicious anger; contemptuous hate.
     With all thy despite against the land of Israel.   --Ezek. xxv. 6.
  2. An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
     A despite done against the Most High.   --Milton.
  In despite, in defiance of another's power or inclination.
  In despite of, in defiance of; in spite of. See under Spite. “Seized my hand in despite of my efforts to the contrary.” --W. Irving.
  In your despite, in defiance or contempt of you; in spite of you. [Obs.]