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From: Webster's Revised Unabridged Dictionary (1913)

 Lose v. t. [imp. & p. p. Lost p. pr. & vb. n. Losing ]
 1. To part with unintentionally or unwillingly, as by accident, misfortune, negligence, penalty, forfeit, etc.; to be deprived of; as, to lose money from one's purse or pocket, or in business or gaming; to lose an arm or a leg by amputation; to lose men in battle.
 Fair Venus wept the sad disaster
 Of having lost her favorite dove.   --Prior.
 2. To cease to have; to possess no longer; to suffer diminution of; as, to lose one's relish for anything; to lose one's health.
    If the salt hath lost his savor, wherewith shall it be salted?   --Matt. v. 13.
 3. Not to employ; to employ ineffectually; to throw away; to waste; to squander; as, to lose a day; to lose the benefits of instruction.
    The unhappy have but hours, and these they lose.   --Dryden.
 4. To wander from; to miss, so as not to be able to and; to go astray from; as, to lose one's way.
    He hath lost his fellows.   --Shak
 5. To ruin; to destroy; as destroy; as, the ship was lost on the ledge.
    The woman that deliberates is lost.   --Addison.
 6. To be deprived of the view of; to cease to see or know the whereabouts of; as, he lost his companion in the crowd.
 Like following life thro' creatures you dissect,
 You lose it in the moment you detect.   --Pope.
 7. To fail to obtain or enjoy; to fail to gain or win; hence, to fail to catch with the mind or senses; to miss; as, I lost a part of what he said.
    He shall in no wise lose his reward.   --Matt. x. 42.
 I fought the battle bravely which I lost,
 And lost it but to Macedonians.   --Dryden.
 8. To cause to part with; to deprive of. [R.]
    How should you go about to lose him a wife he loves with so much passion?   --Sir W. Temple.
 9. To prevent from gaining or obtaining.
    O false heart! thou hadst almost betrayed me to eternal flames, and lost me this glory.   --Baxter.
 To lose ground, to fall behind; to suffer gradual loss or disadvantage.
 To lose heart, to lose courage; to become timid. “The mutineers lost heart.” --Macaulay.
 To lose one's head, to be thrown off one's balance; to lose the use of one's good sense or judgment, through fear, anger, or other emotion.
    In the excitement of such a discovery, many scholars lost their heads.   --Whitney.
 -- To lose one's self. (a) To forget or mistake the bearing of surrounding objects; as, to lose one's self in a great city. (b) To have the perceptive and rational power temporarily suspended; as, we lose ourselves in sleep.
 To lose sight of. (a) To cease to see; as, to lose sight of the land. (b) To overlook; to forget; to fail to perceive; as, he lost sight of the issue.